Investigation of phenolic compounds, in vitro antioxidant and enzyme inhibition activities of methanol and aqueous extracts of different parts of Glaucosciadium cordifolium

The present study was designed to evaluate the biological potentials and phenolic composition of different parts Glaucosciadium cordifolium, which is less investigated known as a wild endemic species Turkey. antioxidant activity plant determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid) (ABTS), iron chelating capacity, ?-carotene / linoleic acid emulsion assay. total phenol flavonoid contents were Folin-Ciocalteu aluminum chloride methods, respectively. enzyme inhibition carried out for acetylcholinesterase, butyrylcholinesterase, ?-glucosidase, ?-amylase, tyrosinase. antiglycation aqueous extract evaluated established methods such browning, Nitroblue-tetrazolium (NBT) assay, 2,4-dinitrophenyl hydrazine (DNPH) method, Congo red fluorescent Bovine Serum Albumin (BSA). HPLC profiling phenolics revealed that 18 standard compounds found in amounts various extracts parts. According our bioactivity results, methanol obtained from flower contained higher flavonoids, also demonstrated highest DPPH radical scavenging activity. In addition, leaves roots be most active against acetylcholinesterase enzyme, well moderately tyrosinase enzyme. capacity followed this order: G. cordifolium > stems flower. As result, indicated have strong potential, good inhibitory effects potential. Further studies on with vivo bioassays need seek importance pharmaceutical techniques.